The average bus between Fresno and Otay Mesa takes 9h 44m and the fastest bus takes 9h 3m. The bus service runs several times per day from Fresno to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Fresno and Otay Mesa. The earliest departure is at 7:30 AM in the morning, and the last departure from Fresno is at 8:00 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro and take an average of 9h 44m. The schedules shown below are for the next available departures.


9h 19m • 2 changes
Arrives next day


9h 55m • 2 changes


9h 54m • 2 changes
Arrives next day


10h 10m • 2 changes


9h 9m • 2 changes
Arrives next day


9h 3m • 2 changes


9h 19m • 2 changes
Arrives next day


9h 3m • 2 changes
Want to know about travelling from Fresno to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Fresno to Otay Mesa. However, there are services departing from Fresno station and arriving at Otay Mesa station via San Ysidro. The journey, including transfers, takes approximately 9h 44m.
Fresno to Otay Mesa bus services, operated by Tufesa, depart from Fresno station.
Fresno to Otay Mesa bus services, operated by Tufesa, arrive at San Ysidro station.
The distance between Fresno and Otay Mesa is 530.4 km. The road distance is 626 km.
International Bus Lines operates a bus from Fresno to San Ysidro 4 times a day, and the journey takes 8h. Two other operators also service this route.