The average bus between Gainesville and Port Saint Lucie takes 10h 6m and the fastest bus takes 6h. The bus service runs several times per day from Gainesville to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Gainesville and Port Saint Lucie. The earliest departure is at 8:25 AM in the morning, and the last departure from Gainesville is at 9:20 PM which arrives into Port Saint Lucie at 12:45 PM. All services require a transfer at Orlando - RedCoach Station, FL and take an average of 10h 6m. The schedules shown below are for the next available departures.

7h 15m • 1 change

9h • 1 change
Arrives next day

15h 25m • 1 change

7h 15m • 1 change

6h • 1 change
Arrives next day

15h 25m • 1 change

7h 15m • 1 change

9h • 1 change
Arrives next day

15h 25m • 1 change
Want to know about travelling from Gainesville to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Gainesville to Port Saint Lucie. However, there are services departing from Gainesville station and arriving at Port Saint Lucie station via Orlando - RedCoach Station, FL station. The journey, including transfers, takes approximately 10h 6m.
Gainesville to Port Saint Lucie bus services, operated by RedCoach, depart from University of Florida - 1956 Gale Lemerand Dr station.
Gainesville to Port Saint Lucie bus services, operated by RedCoach, arrive at Fort Pierce station.
Book your Gainesville to Port Saint Lucie bus tickets online with RedCoach.
The distance between Gainesville and Port Saint Lucie is 325.5 km. The road distance is 370 km.
You can take a bus from University of Florida - 1956 Gale Lemerand Dr to Fort Pierce via Orlando - RedCoach Station, FL and Orlando RedCoach Station in around 4h 53m.