The average bus between Genoa and Lucerne takes 8h 18m and the fastest bus takes 6h 30m. The bus service runs several times per day from Genoa to Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Genoa and Lucerne. The earliest departure is at 8:40 AM in the morning, and the last departure from Genoa is at 7:40 PM which arrives into Lucerne at 12:10 AM. All services require a transfer, and take on average 8h 18m. The schedules shown below are for the next available departures.

5h 45m • 1 change

7h 30m • 1 change
Arrives next day

6h 40m • 1 change

5h 45m • 1 change

8h • 1 change
Arrives next day

4h 30m • 1 change

5h 45m • 1 change

8h • 1 change
Arrives next day

4h 30m • 1 change
Want to know about travelling from Genoa to Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Genoa to Lucerne. However, there are services departing from Genoa station and arriving at Lucerne station via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 8h 18m.
Genoa to Lucerne bus services, operated by FlixBus, depart from Genoa station.
Genoa to Lucerne bus services, operated by FlixBus, arrive at Luzern station.
Book your Genoa to Lucerne bus tickets online with FlixBus and RegioJet.
The distance between Genoa and Lucerne is 298.3 km. The road distance is 393 km.
You can take a bus from Genoa to Luzern via Milan in around 7h 30m.