The average bus between Greenville and Chicago takes 34h 52m and the fastest bus takes 29h 5m. The bus service runs several times per day from Greenville to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Greenville and Chicago. The earliest departure is at 4:00 PM in the afternoon, and the last departure from Greenville is at 6:20 PM which arrives into Chicago at 10:00 AM. All services require a transfer at Raleigh Bus Station and take an average of 34h 52m. The schedules shown below are for the next available departures.
Arrives next day


28h 5m • 2 changes
Arrives +2 days


39h 40m • 2 changes
Arrives next day


28h 5m • 2 changes
Arrives +2 days


39h 40m • 2 changes
Arrives next day


28h 5m • 2 changes
Arrives +2 days


39h 40m • 2 changes
Want to know about travelling from Greenville to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Greenville to Chicago. However, there are services departing from Greenville station and arriving at Chicago station via Raleigh Bus Station station. The journey, including transfers, takes approximately 34h 52m.
Greenville to Chicago bus services, operated by Greyhound USA, depart from Greenville GK Butterfield Trans Ctr station.
Greenville to Chicago bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Book your Greenville to Chicago bus tickets online with Greyhound USA.
The distance between Greenville and Chicago is 1,128.6 km. The road distance is 1,690 km.
You can take a bus from Greenville GK Butterfield Trans Ctr to Chicago Bus Station via Raleigh Bus Station and Washington Union Station in around 25h 8m.