The average bus between Guadalajara and Santander takes 6h 49m and the fastest bus takes 6h 30m. The bus service runs several times per day from Guadalajara to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Guadalajara and Santander. The earliest departure is at 9:30 AM in the morning, and the last departure from Guadalajara is at 11:35 PM which arrives into Santander at 6:30 AM. All services require a transfer, and take on average 6h 49m. The schedules shown below are for the next available departures.

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6h 45m • 1 changeWant to know about travelling from Guadalajara to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Guadalajara to Santander. However, there are services departing from Guadalajara station and arriving at Santander station via Madrid, Avenida de América. The journey, including transfers, takes approximately 6h 49m.
Guadalajara to Santander bus services, operated by ALSA, depart from Guadalajara station.
Guadalajara to Santander bus services, operated by ALSA, arrive at Estación de autobuses de Santander station.
Book your Guadalajara to Santander bus tickets online with ALSA.
The distance between Guadalajara and Santander is 319.8 km. The road distance is 459 km.
You can take a bus from Guadalajara to Estación de autobuses de Santander via Madrid, Avenida de América in around 7h 25m.