The bus between Guadalajara and Mezcales takes 4h 20m. There is a bus service every few hours from Guadalajara to Mezcales. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Guadalajara and Mezcales. The earliest departure is at 6:30 AM in the morning, and the last departure from Guadalajara is at 9:30 PM which arrives into Mezcales at 1:50 AM. All services require a transfer at Central de Autobuses Zapopan and take an average of 4h 20m. The schedules shown below are for the next available departures.

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Want to know about travelling from Guadalajara to Mezcales? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Guadalajara to Mezcales. However, there are services departing from Guadalajara station and arriving at Mezcales station via Mezcales. The journey, including transfers, takes approximately 4h 20m.
Guadalajara to Mezcales bus services, operated by Autotransportes Etzatlán (ATE), depart from Terminal Zapopan station.
Guadalajara to Mezcales bus services, operated by Autotransportes Etzatlán (ATE), arrive at Mezcales station.
The distance between Guadalajara and Mezcales is 196.8 km. The road distance is 273 km.
Vallarta Plus operates a bus from Terminal Zapopan to Mezcales hourly. Tickets cost $367–938 and the journey takes 3h 50m.