Rome2Rio

Hamilton to St. Louis buses

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Trip Overview

The average bus between Hamilton and St. Louis takes 34h 55m and the fastest bus takes 34h 45m. The bus runs, on average, 4 times per week from Hamilton to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

34h 55m
Duration
779 mi
Distance
$151
Average price
4 times a week
Frequency

Hamilton to St. Louis bus times

Buses run 4 times a week between Hamilton and St. Louis. The earliest departure is at 10:10 PM at night, and the last departure from Hamilton is at 10:30 PM which arrives into St. Louis at 8:15 AM. All services require a transfer at Square One and take an average of 34h 55m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    GO TransitFlixbus USABarons BusGreyhound USA34h 45m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    GO TransitFlixbus USABarons BusGreyhound USA34h 45m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    GO TransitFlixbus USABarons BusGreyhound USA35h 5m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    GO TransitFlixbus USABarons BusGreyhound USA35h 5m • 3 changes

Frequently asked questions

Want to know about travelling from Hamilton to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Hamilton to St. Louis.ExpandLaunch map view
  • Distance: 778.6 mi
  • Duration: 34h 55m

What companies run services between Hamilton, ON, Canada and St. Louis, MO, USA?

You can take a bus from Hamilton GO Centre Bus to St Louis Bus Station via Square One, Mississauga, Detroit, and Indianapolis Union Station in around 19h 21m.

Operators