The average bus between Harlem and Buffalo takes 9h 52m and the fastest bus takes 9h 28m. The bus service runs several times per day from Harlem to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Harlem and Buffalo. The earliest departure is at 6:55 AM in the morning, and the last departure from Harlem is at 11:10 PM which arrives into Buffalo at 7:45 AM. All services require a transfer at 42 St-Port Authority Bus Terminal and take an average of 9h 52m. The schedules shown below are for the next available departures.

9h 51m • 1 change
9h 50m • 1 change
9h 57m • 1 change
9h 41m • 1 change
10h 5m • 1 change
10h 10m • 1 change
10h • 1 change
9h 45m • 1 change
10h 5m • 1 change
10h 10m • 1 change
10h • 1 change
9h 45m • 1 changeWant to know about travelling from Harlem to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Buffalo. However, there are services departing from New York station and arriving at Buffalo station via Buffalo station. The journey, including transfers, takes approximately 9h 52m.
Harlem to Buffalo bus services, operated by Trailways, depart from New York station.
Harlem to Buffalo bus services, operated by Trailways, arrive at Buffalo station.
The distance between Harlem and Buffalo is 469.3 km. The road distance is 582 km.
Trailways operates a bus from New York to Buffalo 5 times a day. Tickets cost $60–280 and the journey takes 8h.