The average bus between Harlem and Hyannis takes 7h 49m and the fastest bus takes 6h 56m. The bus service runs several times per day from Harlem to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Harlem and Hyannis. The earliest departure is at 12:38 AM at night, and the last departure from Harlem is at 5:53 PM which arrives into Hyannis at 1:35 AM. All services require a transfer at 42 St-Port Authority Bus Terminal and take an average of 7h 49m. The schedules shown below are for the next available departures.


7h 27m • 2 changes

8h 26m • 2 changes

7h 28m • 2 changes

6h 56m • 2 changes

7h 37m • 2 changes

8h 27m • 2 changes

7h 37m • 2 changes

7h 4m • 2 changes

7h 37m • 2 changes

8h 27m • 2 changes

7h 37m • 2 changes

8h 25m • 2 changes

7h 37m • 2 changes

8h 27m • 2 changes

7h 37m • 2 changes

8h 10m • 2 changes

7h 37m • 2 changes

8h 27m • 2 changes

7h 37m • 2 changes

7h 4m • 2 changesWant to know about travelling from Harlem to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Hyannis. However, there are services departing from Harlem station and arriving at Hyannis station via Boston. The journey, including transfers, takes approximately 7h 49m.
Harlem to Hyannis bus services, operated by MTA Bus Company, depart from New York station.
Harlem to Hyannis bus services, operated by MTA Bus Company, arrive at Hyannis Transportation Center station.
The distance between Harlem and Hyannis is 320.4 km. The road distance is 467 km.
You can take a subway from 125 St to Hyannis Transportation Center via 42 St-Port Authority Bus Terminal, New York, Boston, and Boston South Buses in around 8h 17m.