The average bus between Harlem and Syracuse takes 5h 59m and the fastest bus takes 5h 22m. The bus service runs several times per day from Harlem to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Harlem and Syracuse. The earliest departure is at 12:38 AM at night, and the last departure from Harlem is at 10:04 PM which arrives into Syracuse at 3:55 AM. All services require a transfer at 34 St-Penn Station and take an average of 5h 59m. The schedules shown below are for the next available departures.

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Want to know about travelling from Harlem to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Syracuse. However, there are services departing from Harlem station and arriving at Syracuse station via Syracuse Bus Station station. The journey, including transfers, takes approximately 5h 59m.
Harlem to Syracuse bus services, operated by MTA Bus Company, depart from New York Midtown station.
Harlem to Syracuse bus services, operated by MTA Bus Company, arrive at Syracuse Bus Station.
The distance between Harlem and Syracuse is 308.6 km. The road distance is 467 km.
Flixbus USA operates a bus from New York Midtown to Syracuse Bus Station every 4 hours. Tickets cost $45–80 and the journey takes 5h 10m.