The average bus between Harrisburg Airport (MDT) and Chicago takes 20h 19m and the fastest bus takes 17h 24m. There is at least one bus per day from Harrisburg Airport (MDT) to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Harrisburg Airport (MDT) and Chicago. The earliest departure is at 12:31 PM in the afternoon, and the last departure from Harrisburg Airport (MDT) is at 9:01 PM which arrives into Chicago at 6:55 PM. All services require a transfer at S 2nd St & Chestnut St NB and take an average of 20h 19m. The schedules shown below are for the next available departures.
Arrives next day

16h 24m • 1 change
Arrives next day

21h 54m • 1 change
Arrives next day

17h 39m • 1 change
Arrives next day

22h 24m • 1 change
Want to know about travelling from Harrisburg Airport (MDT) to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harrisburg Airport (MDT) to Chicago. However, there are services departing from Harrisburg Airport (MDT) station and arriving at Chicago station via Chicago Bus Station station. The journey, including transfers, takes approximately 20h 19m.
Harrisburg Airport (MDT) to Chicago bus services, operated by Rabbit Transit, depart from Harrisburg Bus Station.
Harrisburg Airport (MDT) to Chicago bus services, operated by Rabbit Transit, arrive at Chicago Bus Station.
Book your Harrisburg Airport (MDT) to Chicago bus tickets online with Rabbit Transit and Flixbus USA.
The distance between Harrisburg Airport (MDT) and Chicago is 930.1 km. The road distance is 1,267 km.
Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station 3 times a day. Tickets cost $120–210 and the journey takes 16h 30m.