The average bus between Harrisburg and Des Moines takes 33h 33m and the fastest bus takes 29h 5m. The bus service runs several times per day from Harrisburg to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Harrisburg and Des Moines. The earliest departure is at 2:15 AM at night, and the last departure from Harrisburg is at 2:40 PM which arrives into Des Moines at 6:55 PM. All services require a transfer, and take on average 33h 33m. The schedules shown below are for the next available departures.
Arrives next day

36h 20m • 1 change
Arrives next day

28h 5m • 1 change
Arrives next day

36h 20m • 1 change
Arrives next day

28h 5m • 1 change
Arrives next day

36h 20m • 1 change
Arrives next day

28h 5m • 1 change
Arrives next day

36h 20m • 1 change
Arrives next day

28h 5m • 1 change
Want to know about travelling from Harrisburg to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harrisburg to Des Moines. However, there are services departing from Harrisburg station and arriving at Des Moines station via Chicago Bus Station station. The journey, including transfers, takes approximately 33h 33m.
Harrisburg to Des Moines bus services, operated by Flixbus USA, depart from Harrisburg Bus Station.
Harrisburg to Des Moines bus services, operated by Flixbus USA, arrive at Des Moines station.
Book your Harrisburg to Des Moines bus tickets online with Flixbus USA and Greyhound USA.
The distance between Harrisburg and Des Moines is 1,410.4 km. The road distance is 1,787 km.
You can take a bus from Harrisburg Bus Station to Des Moines via Chicago Bus Station in around 24h.