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Harrisburg, Pa to Chicago buses

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Trip Overview

The average bus between Harrisburg, Pa and Chicago takes 16h 48m and the fastest bus takes 16h 30m. There is at least one bus per day from Harrisburg, Pa to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 48m
Duration
777 mi
Distance
$150
Average price
Once daily
Frequency

Harrisburg, Pa to Chicago bus times

Buses run once daily between Harrisburg, Pa and Chicago. The earliest departure is at 2:30 AM at night, and the last departure from Harrisburg, Pa is at 2:40 PM which arrives into Chicago at 6:10 AM. All services run direct with no transfers required, and take on average 16h 48m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    bus bus 16h 30m • Direct

Departing Friday, November 13, 2026

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    Arrives next day

    bus bus 16h 30m • Direct

Departing Saturday, November 14, 2026

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    bus bus 17h 25m • Direct
  •  → 

    Arrives next day

    bus bus 16h 30m • Direct

Departing Sunday, November 15, 2026

  •  → 

    bus bus 17h 25m • Direct
  •  → 

    Arrives next day

    bus bus 16h 30m • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 17h 25m • Direct
  •  → 

    Arrives next day

    bus bus 16h 30m • Direct

Departing Wednesday, November 18, 2026

  •  → 

    Arrives next day

    bus bus 16h 30m • Direct

Frequently asked questions

Want to know about travelling from Harrisburg, Pa to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Harrisburg, Pa to Chicago.ExpandLaunch map view
  • Distance: 776.9 mi
  • Duration: 16h 48m

What companies run services between Harrisburg, Pa, PA, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $120–190 and the journey takes 16h 30m.

Operators