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Harrisburg, Pa to Des Moines buses

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Trip Overview

The bus between Harrisburg, Pa and Des Moines takes 26h 55m. There is at least one bus per day from Harrisburg, Pa to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

26h 55m
Duration
1,023 mi
Distance
$222
Average price
Once daily
Frequency

Harrisburg, Pa to Des Moines bus times

Buses run once daily between Harrisburg, Pa and Des Moines. The service departs Harrisburg, Pa at 7:50 PM in the evening, which arrives into Des Moines at 21:45:00. All services require a transfer, and take on average 26h 55m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USA26h 55m • 1 change

Frequently asked questions

Want to know about travelling from Harrisburg, Pa to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Harrisburg, Pa to Des Moines.ExpandLaunch map view
  • Distance: 1,023.1 mi
  • Duration: 26h 55m

What companies run services between Harrisburg, Pa, PA, USA and Des Moines, IA, USA?

You can take a bus from Harrisburg Bus Station to Des Moines via Indianapolis Union Station in around 24h 15m.

Operators