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Harrisburg, Pa to Des Moines buses

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Trip Overview

The average bus between Harrisburg, Pa and Des Moines takes 35h 20m and the fastest bus takes 29h 5m. There is at least one bus per day from Harrisburg, Pa to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 20m
Duration
1,117 mi
Distance
$216
Average price
Once daily
Frequency

Harrisburg, Pa to Des Moines bus times

Buses run once daily between Harrisburg, Pa and Des Moines. The earliest departure is at 2:30 AM at night, and the last departure from Harrisburg, Pa is at 2:40 PM which arrives into Des Moines at 6:45 PM. All services require a transfer, and take on average 35h 20m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA29h 5m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA29h 5m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA37h 5m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA29h 5m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA37h 5m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA37h 5m • 1 change
  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USA2d • 1 change

Frequently asked questions

Want to know about travelling from Harrisburg, Pa to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Harrisburg, Pa to Des Moines.ExpandLaunch map view
  • Distance: 1,116.9 mi
  • Duration: 35h 20m

What companies run services between Harrisburg, Pa, PA, USA and Des Moines, IA, USA?

You can take a bus from Harrisburg Bus Station to Des Moines via Chicago Bus Station in around 24h.

Operators