The average bus between Heilbronn and Brno takes 9h 41m and the fastest bus takes 9h 5m. The bus service runs several times per day from Heilbronn to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Heilbronn and Brno. The earliest departure is at 1:25 AM at night, and the last departure from Heilbronn is at 3:30 PM which arrives into Brno at 1:05 AM. All services require a transfer, and take on average 9h 41m. The schedules shown below are for the next available departures.

9h 5m • 1 change

10h 20m • 1 change
Arrives next day

9h 35m • 1 change

9h 5m • 1 change

10h 20m • 1 change
Arrives next day

9h 35m • 1 change

9h 5m • 1 change

10h 20m • 1 change
Arrives next day

9h 35m • 1 change

9h 5m • 1 change

10h 20m • 1 change
Arrives next day

9h 35m • 1 change
Want to know about travelling from Heilbronn to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Heilbronn to Brno. However, there are services departing from Heilbronn station and arriving at Brno station via Praha, ÚAN Florenc. The journey, including transfers, takes approximately 9h 41m.
Heilbronn to Brno bus services, operated by FlixBus, depart from Heilbronn central train station.
Heilbronn to Brno bus services, operated by FlixBus, arrive at Brno station.
Book your Heilbronn to Brno bus tickets online with FlixBus and RegioJet.
The distance between Heilbronn and Brno is 536.9 km. The road distance is 666 km.
You can take a bus from Heilbronn central train station to Brno via Praha, ÚAN Florenc in around 9h 40m.