The average bus between High Wycombe and Penzance takes 10h 14m and the fastest bus takes 9h 32m. The bus service runs several times per day from High Wycombe to Penzance. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between High Wycombe and Penzance. The earliest departure is at 7:39 AM in the morning, and the last departure from High Wycombe is at 9:33 PM which arrives into Penzance at 7:05 AM. All services require a transfer, and take on average 10h 14m. The schedules shown below are for the next available departures.

11h 1m • 1 change

10h 1m • 1 change

10h 41m • 1 change
Arrives next day

9h 32m • 1 change

11h 1m • 1 change

10h 1m • 1 change

10h 41m • 1 change
Arrives next day

9h 32m • 1 change

11h 1m • 1 change

10h 1m • 1 change

10h 41m • 1 change
Arrives next day

9h 32m • 1 change

11h 1m • 1 change

10h 1m • 1 change

10h 56m • 1 change
Arrives next day

9h 32m • 1 change

10h 11m • 1 change

9h 51m • 1 change

10h 26m • 1 change
Arrives next day

9h 32m • 1 change
Want to know about travelling from High Wycombe to Penzance? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from High Wycombe to Penzance. However, there are services departing from High Wycombe station and arriving at Penzance station via Bus Station station. The journey, including transfers, takes approximately 10h 14m.
High Wycombe to Penzance bus services, operated by Carousel Buses, depart from Heathrow Central Bus Station.
High Wycombe to Penzance bus services, operated by Carousel Buses, arrive at Bus Station.
Book your High Wycombe to Penzance bus tickets online with Carousel Buses and National Express.
The distance between High Wycombe and Penzance is 375.5 km. The road distance is 507 km.
National Express operates a bus from Heathrow Central Bus Station to Bus Station every 4 hours. Tickets cost £55–140 and the journey takes 7h 50m.