The average bus between Hoboken and Hyannis takes 7h 34m and the fastest bus takes 6h 20m. There is at least one bus per day from Hoboken to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Hoboken and Hyannis. The earliest departure is at 6:30 AM in the morning, and the last departure from Hoboken is at 9:00 PM which arrives into Hyannis at 12:50 PM. All services require a transfer, and take on average 7h 34m. The schedules shown below are for the next available departures.

6h 20m • 1 change

6h 20m • 1 change

6h 45m • 1 change

6h 45m • 1 change
Want to know about travelling from Hoboken to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hoboken to Hyannis. However, there are services departing from Hoboken station and arriving at Hyannis station via Peter Pan Bus Terminal. The journey, including transfers, takes approximately 7h 34m.
Hoboken to Hyannis bus services, operated by Peter Pan Bus Lines, depart from Port Authority Bus Terminal station.
Hoboken to Hyannis bus services, operated by Peter Pan Bus Lines, arrive at Hyannis Transportation Center station.
Book your Hoboken to Hyannis bus tickets online with Peter Pan Bus Lines.
The distance between Hoboken and Hyannis is 329.2 km. The road distance is 416 km.
You can take a bus from Port Authority Bus Terminal to Hyannis Transportation Center via Providence Bus Terminal in around 6h 50m.