Hotel Pisa, Rome to Florence Buses

Trip Overview

The average bus between Hotel Pisa, Rome and Florence takes 4h 7m and the fastest bus takes 3h 44m. There is a bus service every few hours from Hotel Pisa, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 7m
Duration: 280 km
Distance: €32
Average price: Hourly
Frequency

Bus

best

Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

3h 50m

€16–48

Hotel Pisa, Rome to Florence bus times

Buses run hourly between Hotel Pisa, Rome and Florence. The earliest departure is at 5:49 AM in the morning, and the last departure from Hotel Pisa, Rome is at 10:25 PM which arrives into Florence at 2:10 AM. All services require a transfer at Conte Verde/Manzoni and take an average of 4h 7m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

10:16 PM → 2:10 AM
Arrives next day
3h 53m • 1 change

Departing Friday, November 6, 2026

5:50 AM → 10:15 AM
4h 24m • 1 change
7:21 AM → 11:10 AM
3h 48m • 1 change
7:35 AM → 11:45 AM
4h 9m • 1 change
8:05 AM → 12:30 PM
4h 24m • 1 change
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Departing Saturday, November 7, 2026

5:49 AM → 10:15 AM
4h 25m • 1 change
7:19 AM → 11:10 AM
3h 50m • 1 change
7:37 AM → 11:45 AM
4h 7m • 1 change
8:16 AM → 12:30 PM
4h 13m • 1 change
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Departing Sunday, November 8, 2026

5:49 AM → 10:15 AM
4h 25m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:34 AM → 11:45 AM
4h 10m • 1 change
7:59 AM → 12:30 PM
4h 30m • 1 change
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Departing Monday, November 9, 2026

5:50 AM → 10:15 AM
4h 24m • 1 change
7:21 AM → 11:10 AM
3h 48m • 1 change
7:35 AM → 11:45 AM
4h 9m • 1 change
8:05 AM → 12:30 PM
4h 24m • 1 change
Show more

Departing Tuesday, November 10, 2026

5:50 AM → 10:15 AM
4h 24m • 1 change
7:21 AM → 11:10 AM
3h 48m • 1 change
7:35 AM → 11:45 AM
4h 9m • 1 change
8:05 AM → 12:30 PM
4h 24m • 1 change
Show more

Departing Wednesday, November 11, 2026

7:21 AM → 11:10 AM
3h 48m • 1 change
7:35 AM → 11:45 AM
4h 9m • 1 change
8:05 AM → 12:30 PM
4h 24m • 1 change
9:28 AM → 1:25 PM
3h 56m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Hotel Pisa, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.