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Hotel dei Mellini, Rome to Florence buses

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Trip Overview

The average bus between Hotel dei Mellini, Rome and Florence takes 4h 12m and the fastest bus takes 3h 44m. There is a bus service every few hours from Hotel dei Mellini, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 12m
Duration
286 km
Distance
€30
Average price
Hourly
Frequency

Bus

best
  1. Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus bus 510 / ...
4h 39m
€16–44

Hotel dei Mellini, Rome to Florence bus times

Buses run hourly between Hotel dei Mellini, Rome and Florence. The earliest departure is at 5:44 AM in the morning, and the last departure from Hotel dei Mellini, Rome is at 10:20 PM which arrives into Florence at 2:10 AM. All services require a transfer at Lepanto and take an average of 4h 12m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 12m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 59m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 59m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 12m • 1 change
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Departing Saturday, October 10, 2026

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    ATAC S.p.A. Azienda per la mobilitàItabus S.p.A.3h 44m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 55m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 56m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 3m • 1 change
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Departing Sunday, October 11, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 30m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 5m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 14m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 56m • 1 change
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Frequently asked questions

Want to know about travelling from Hotel dei Mellini, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Hotel dei Mellini, Rome to Florence.ExpandLaunch map view
  • Distance: 286.1 km
  • Duration: 4h 12m

What companies run services between Hotel dei Mellini, Rome, Italy and Florence, Italy?

FlixBus operates a bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Station hourly. Tickets cost €22–35 and the journey takes 3h 15m. Three other operators also service this route.

Operators