The average bus between Houston and Winston-Salem takes 27h 7m and the fastest bus takes 25h 31m. The bus service runs several times per day from Houston to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Houston and Winston-Salem. The earliest departure is at 1:21 AM at night, and the last departure from Houston is at 12:13 PM which arrives into Winston-Salem at 2:45 PM. All services require a transfer at Magnolia Transit Center and take an average of 27h 7m. The schedules shown below are for the next available departures.
Arrives next day


29h 37m • 2 changes
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26h 44m • 2 changes
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29h 37m • 2 changes
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26h 31m • 2 changes
Arrives next day


29h 38m • 2 changes
Arrives next day


26h 31m • 2 changes
Want to know about travelling from Houston to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Houston to Winston-Salem. However, there are services departing from Houston station and arriving at Winston-Salem station via Atlanta. The journey, including transfers, takes approximately 27h 7m.
Houston to Winston-Salem bus services, operated by Metropolitan Transit Harris County, depart from Houston - Harrisburg Blvd station.
Houston to Winston-Salem bus services, operated by Metropolitan Transit Harris County, arrive at Winston Salem(Trans Center) station.
Book your Houston to Winston-Salem bus tickets online with Metropolitan Transit Harris County and Greyhound USA.
The distance between Houston and Winston-Salem is 1,574.6 km. The road distance is 1,979 km.
You can take a bus from Louisiana St @ Preston St to Winston Salem(Trans Center) via Magnolia Transit Center, Houston - Harrisburg Blvd, Atlanta, Doraville Station, Civic Center Station, Atlanta Downtown, and Charlotte Bus Station in around 23h 16m.