Hyannis to Brookline Buses

Hyannis to Brookline buses

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Trip Overview

The average bus between Hyannis and Brookline takes 2h 24m and the fastest bus takes 2h 12m. There is a bus service every few hours from Hyannis to Brookline. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 24m
Duration: 74 mi
Distance: $22
Average price: Hourly
Frequency

Bus

best

Take the bus from Hyannis to Bostonbus Bz 0947 / ...

2h 7m

$19–34

Hyannis to Brookline bus times

Buses run hourly between Hyannis and Brookline. The earliest departure is at 4:00 AM at night, and the last departure from Hyannis is at 9:00 PM which arrives into Brookline at 11:19 PM. All services require a transfer at Boston and take an average of 2h 24m. The schedules shown below are for the next available departures.

Departing Saturday, September 19, 2026

4:00 PM → 6:26 PM
2h 26m • 1 change
5:30 PM → 7:50 PM
2h 20m • 1 change
6:45 PM → 9:23 PM
2h 38m • 1 change
9:00 PM → 11:25 PM
2h 25m • 1 change

Departing Sunday, September 20, 2026

4:00 AM → 6:36 AM
2h 36m • 1 change
5:00 AM → 7:14 AM
2h 14m • 1 change
6:00 AM → 8:12 AM
2h 12m • 1 change
7:00 AM → 9:24 AM
2h 24m • 1 change
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Departing Monday, September 21, 2026

4:00 AM → 6:14 AM
2h 14m • 1 change
5:00 AM → 7:18 AM
2h 18m • 1 change
6:00 AM → 8:18 AM
2h 18m • 1 change
7:00 AM → 9:22 AM
2h 22m • 1 change
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Departing Tuesday, September 22, 2026

4:00 AM → 6:14 AM
2h 14m • 1 change
5:00 AM → 7:18 AM
2h 18m • 1 change
6:00 AM → 8:18 AM
2h 18m • 1 change
7:00 AM → 9:22 AM
2h 22m • 1 change
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Frequently asked questions

Want to know about travelling from Hyannis to Brookline? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Trip Overview

Bus