Hyannis to Mass General Brigham Buses

Hyannis to Mass General Brigham buses

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Trip Overview

The average bus between Hyannis and Mass General Brigham takes 2h 40m and the fastest bus takes 2h 15m. There is a bus service every few hours from Hyannis to Mass General Brigham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 40m
Duration: 72 mi
Distance: $20
Average price: Hourly
Frequency

Bus

best

Take the bus from Hyannis to Bostonbus Bz 0947 / ...

2h 1m

$17–27

Hyannis to Mass General Brigham bus times

Buses run hourly between Hyannis and Mass General Brigham. The earliest departure is at 3:00 AM at night, and the last departure from Hyannis is at 6:45 PM which arrives into Mass General Brigham at 9:45 PM. All services require a transfer at Boston and take an average of 2h 40m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

5:00 AM → 7:45 AM
2h 45m • 1 change
6:30 AM → 8:45 AM
2h 15m • 1 change
7:00 AM → 9:45 AM
2h 45m • 1 change
8:00 AM → 10:45 AM
2h 45m • 1 change
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Departing Saturday, October 10, 2026

3:00 AM → 6:15 AM
3h 15m • 1 change
4:00 AM → 6:45 AM
2h 45m • 1 change
5:00 AM → 7:45 AM
2h 45m • 1 change
6:30 AM → 8:45 AM
2h 15m • 1 change
Show more

Departing Sunday, October 11, 2026

3:00 AM → 6:15 AM
3h 15m • 1 change
4:00 AM → 6:45 AM
2h 45m • 1 change
5:00 AM → 7:45 AM
2h 45m • 1 change
6:30 AM → 8:45 AM
2h 15m • 1 change
Show more

Departing Monday, October 12, 2026

3:00 AM → 6:15 AM
3h 15m • 1 change
4:00 AM → 6:45 AM
2h 45m • 1 change
5:00 AM → 7:45 AM
2h 45m • 1 change
6:30 AM → 8:45 AM
2h 15m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Hyannis to Mass General Brigham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Hyannis to Mass General Brigham buses

Trip Overview

Bus