The average bus between Hyannis and Worcester takes 3h 35m and the fastest bus takes 2h 45m. The bus service runs several times per day from Hyannis to Worcester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Hyannis and Worcester. The earliest departure is at 4:30 AM at night, and the last departure from Hyannis is at 7:00 PM which arrives into Worcester at 10:00 PM. All services require a transfer, and take on average 3h 35m. The schedules shown below are for the next available departures.

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2h 59m • 1 changeWant to know about travelling from Hyannis to Worcester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hyannis to Worcester. However, there are services departing from Hyannis station and arriving at Worcester station via Boston. The journey, including transfers, takes approximately 3h 35m.
Hyannis to Worcester bus services, operated by Peter Pan Bus Lines, depart from Hyannis station.
Hyannis to Worcester bus services, operated by Peter Pan Bus Lines, arrive at Worcester station.
Book your Hyannis to Worcester bus tickets online with Peter Pan Bus Lines, Flixbus USA and Greyhound USA.
The distance between Hyannis and Worcester is 142.8 km. The road distance is 182 km.
You can take a bus from Hyannis to Worcester via Boston in around 3h 18m.