The average bus between Indianapolis and DeSoto takes 25h and the fastest bus takes 21h 30m. The bus service runs several times per day from Indianapolis to DeSoto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Indianapolis and DeSoto. The earliest departure is at 4:40 AM at night, and the last departure from Indianapolis is at 8:10 PM which arrives into DeSoto at 6:15 AM. All services require a transfer at Nashville Bus Station and take an average of 25h. The schedules shown below are for the next available departures.
Arrives next day



25h 35m • 3 changes
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20h 30m • 3 changes
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22h 33m • 3 changes
Arrives next day



25h 35m • 3 changes
Arrives next day



20h 30m • 3 changes
Arrives next day



22h 33m • 3 changes
Arrives next day



25h 35m • 3 changes
Arrives next day



20h 30m • 3 changes
Arrives next day



22h 33m • 3 changes
Arrives +2 days



34h 5m • 3 changes
Want to know about travelling from Indianapolis to DeSoto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Indianapolis to DeSoto. However, there are services departing from Indianapolis station and arriving at DeSoto station via Nashville Bus Station station. The journey, including transfers, takes approximately 25h.
Indianapolis to DeSoto bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
Indianapolis to DeSoto bus services, operated by Greyhound USA, arrive at Dallas Bus Station.
The distance between Indianapolis and DeSoto is 1,247.1 km. The road distance is 1,618 km.
You can take a bus from Indianapolis Union Station to Glenn Heights P & R via Nashville Bus Station, Dallas Bus Station, Bachman Station, and Southwest Medical District/Parkland in around 21h 31m.