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Indianapolis to Florence buses

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Trip Overview

The average bus between Indianapolis and Florence takes 21h 40m and the fastest bus takes 18h 55m. There is at least one bus per day from Indianapolis to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 40m
Duration
865 mi
Distance
$173
Average price
Once daily
Frequency

Indianapolis to Florence bus times

Buses run once daily between Indianapolis and Florence. The service departs Indianapolis at 6:35 PM in the evening, which arrives into Florence at 13:30:00. All services require a transfer, and take on average 21h 40m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Departing Thursday, November 5, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Departing Friday, November 6, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USA18h 55m • 1 change

Frequently asked questions

Want to know about travelling from Indianapolis to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Indianapolis to Florence.ExpandLaunch map view
  • Distance: 865.5 mi
  • Duration: 21h 40m

What companies run services between Indianapolis, IN, USA and Florence, SC, USA?

You can take a bus from Indianapolis to Florence Bus Station via Atlanta Bus Station in around 18h 45m.

Operators