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Indianapolis to Port Saint Lucie buses

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Trip Overview

The average bus between Indianapolis and Port Saint Lucie takes 40h 27m and the fastest bus takes 36h 3m. There is at least one bus per day from Indianapolis to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 27m
Duration
1,141 mi
Distance
$218
Average price
Once daily
Frequency

Indianapolis to Port Saint Lucie bus times

Buses run once daily between Indianapolis and Port Saint Lucie. The earliest departure is at 6:35 PM in the evening, and the last departure from Indianapolis is at 11:20 PM which arrives into Port Saint Lucie at 11:47 AM. All services require a transfer at Atlanta Bus Station and take an average of 40h 27m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie36h 27m • 2 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie36h 27m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie36h 27m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie41h 12m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie41h 12m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAArea Regional Transit St Lucie36h 3m • 2 changes

Frequently asked questions

Want to know about travelling from Indianapolis to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Indianapolis to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,140.7 mi
  • Duration: 40h 27m

What companies run services between Indianapolis, IN, USA and Port Saint Lucie, FL, USA?

You can take a bus from Indianapolis to SW PSL Blvd & Cameo Blvd - East via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 24h 39m.

Operators