Rome2Rio

Indianapolis to San Diego buses

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Trip Overview

The bus between Indianapolis and San Diego takes 2d 6h. The bus runs, on average, 6 times per week from Indianapolis to San Diego. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 6h
Duration
2,266 mi
Distance
$492
Average price
6 times a week
Frequency

Indianapolis to San Diego bus times

Buses run 6 times a week between Indianapolis and San Diego. The service departs Indianapolis at 7:55 PM in the evening, which arrives into San Diego at 23:50:00. All services require a transfer at St Louis Bus Station and take an average of 2d 6h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound Mexico2d 6h • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound Mexico2d 6h • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound Mexico2d 6h • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound Mexico2d 6h • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound Mexico2d 6h • 2 changes

Frequently asked questions

Want to know about travelling from Indianapolis to San Diego? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Indianapolis to San Diego.ExpandLaunch map view
  • Distance: 2,265.8 mi
  • Duration: 2d 6h

What companies run services between Indianapolis, IN, USA and San Diego, CA, USA?

You can take a bus from Indianapolis Union Station to San Diego via St Louis Bus Station and Los Angeles Union Station in around 2d 1h.

Operators