Rome2Rio

Indianapolis to Winston-Salem buses

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Trip Overview

The bus between Indianapolis and Winston-Salem takes 17h 50m. The bus runs, on average, 5 times per week from Indianapolis to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 50m
Duration
598 mi
Distance
$127
Average price
5 times a week
Frequency

Indianapolis to Winston-Salem bus times

Buses run 5 times a week between Indianapolis and Winston-Salem. The service departs Indianapolis at 4:20 PM in the afternoon, which arrives into Winston-Salem at 10:10:00. All services require a transfer at Columbus and take an average of 17h 50m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USACOTAGreyhound USA17h 50m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USACOTAGreyhound USA17h 50m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USACOTAGreyhound USA17h 50m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USACOTAGreyhound USA17h 50m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Flixbus USACOTAGreyhound USA17h 50m • 2 changes

Frequently asked questions

Want to know about travelling from Indianapolis to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Indianapolis to Winston-Salem.ExpandLaunch map view
  • Distance: 598.5 mi
  • Duration: 17h 50m

What companies run services between Indianapolis, IN, USA and Winston-Salem, NC, USA?

You can take a bus from Indianapolis to Winston Salem(Trans Center) via Columbus, E Main St & S High St, S Grant Ave & E Mound St, and Columbus in around 14h 3m.

Operators