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Irvine to Indianapolis buses

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Trip Overview

The average bus between Irvine and Indianapolis takes 3d 2h and the fastest bus takes 2d 22h. The bus runs, on average, 4 times per week from Irvine to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 2h
Duration
2,183 mi
Distance
$408
Average price
4 times a week
Frequency

Irvine to Indianapolis bus times

Buses run 4 times a week between Irvine and Indianapolis. The earliest departure is at 12:07 PM in the afternoon, and the last departure from Irvine is at 11:45 PM which arrives into Indianapolis at 2:30 PM. All services require a transfer at Artic - Dock 4 and take an average of 3d 2h. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USA2d 23h • 3 changes

Departing Saturday, October 10, 2026

  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USA2d 22h • 3 changes
  •  → 

    Arrives +4 days

    OCTAGreyhound USAGreyhound USAGreyhound USA3d 11h • 3 changes

Departing Monday, October 12, 2026

  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USA2d 23h • 3 changes

Frequently asked questions

Want to know about travelling from Irvine to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Indianapolis.ExpandLaunch map view
  • Distance: 2,182.8 mi
  • Duration: 3d 2h

What companies run services between Irvine, CA, USA and Indianapolis, IN, USA?

You can take a bus from Main-Harvard to Indianapolis Union Station via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Montclair Transcenter, and St Louis Bus Station in around 2d 1h.

Operators