Rome2Rio

Irvine to Kearny Mesa buses

Find Transport to Kearny Mesa

View schedule

Trip Overview

The average bus between Irvine and Kearny Mesa takes 5h 43m and the fastest bus takes 3h 39m. The bus service runs several times per day from Irvine to Kearny Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 43m
Duration
110 mi
Distance
$24
Average price
3 times a day
Frequency

Line 53 bus, bus

best
  1. Take the bus from Main-Harvard to Artic - Dock 4bus bus 53
  2. Take the bus from Anaheim Regional Transportation Intermodal Center to San Diego Greyhound Bus Stopbus bus Greyhound US0901 / ...
4h 29m
$17–30

Irvine to Kearny Mesa bus times

Buses run 3 times a day between Irvine and Kearny Mesa. The earliest departure is at 8:31 AM in the morning, and the last departure from Irvine is at 11:45 PM which arrives into Kearny Mesa at 12:31 PM. All services require a transfer at Artic - Dock 4 and take an average of 5h 43m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 39m • 2 changes

  •  → 

    OCTAFlixbus USASan Diego Metro Transit4h 25m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit4h 1m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit9h 4m • 2 changes

Departing Tuesday, October 13, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 39m • 2 changes

  •  → 

    OCTAFlixbus USASan Diego Metro Transit4h 25m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit4h 1m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit9h 4m • 2 changes

Departing Wednesday, October 14, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 39m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit4h 1m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit9h 4m • 2 changes

Departing Thursday, October 15, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 39m • 2 changes

  •  → 

    OCTAFlixbus USASan Diego Metro Transit4h 25m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit4h 1m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit9h 4m • 2 changes

Departing Friday, October 16, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 39m • 2 changes

  •  → 

    OCTAFlixbus USASan Diego Metro Transit4h 25m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit4h 1m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit10h 9m • 2 changes

Departing Saturday, October 17, 2026

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 51m • 2 changes

  •  → 

    OCTAFlixbus USASan Diego Metro Transit3h 53m • 2 changes

  •  → 

    OCTAGreyhound USASan Diego Metro Transit3h 53m • 2 changes

  •  → 

    Arrives next day

    OCTAGreyhound USASan Diego Metro Transit10h 26m • 2 changes
  • Show more

Frequently asked questions

Want to know about travelling from Irvine to Kearny Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Kearny Mesa.ExpandLaunch map view
  • Distance: 110.3 mi
  • Duration: 5h 43m

What companies run services between Irvine, CA, USA and Kearny Mesa, CA, USA?

You can take a bus from Main-Harvard to Clairemont Mesa Bl & 8303 via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, San Diego Greyhound Bus Stop, and Old Town Transit Center in around 4h 29m.

Operators