Irvine to Otay Mesa Buses

Irvine to Otay Mesa buses

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Trip Overview

The average bus between Irvine and Otay Mesa takes 5h 33m and the fastest bus takes 4h 21m. The bus service runs several times per day from Irvine to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 33m
Duration: 127 mi
Distance: $32
Average price: 5 times a day
Frequency

Line 59 bus, bus

best

Take the bus from University-Ent 3773 Mariposa Villa to The Depot At Santa Ana Dock 3bus 59
Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...

4h 35m

$22–39

Irvine to Otay Mesa bus times

Buses run 5 times a day between Irvine and Otay Mesa. The earliest departure is at 5:27 AM in the morning, and the last departure from Irvine is at 10:26 PM which arrives into Otay Mesa at 6:54 AM. All services require a transfer at The Depot At Santa Ana Dock 3 and take an average of 5h 33m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

1:33 PM → 5:54 PM
4h 21m • 3 changes
4:15 PM → 8:54 PM
4h 39m • 3 changes
8:58 PM → 6:10 AM
Arrives next day
9h 12m • 3 changes

Departing Monday, October 12, 2026

5:27 AM → 10:19 AM
4h 52m • 3 changes
8:46 AM → 1:19 PM
4h 33m • 3 changes
1:37 PM → 6:19 PM
4h 42m • 3 changes
2:02 PM → 6:45 PM
4h 43m • 3 changes
Show more

Departing Tuesday, October 13, 2026

5:27 AM → 10:19 AM
4h 52m • 3 changes
8:46 AM → 1:19 PM
4h 33m • 3 changes
1:37 PM → 6:19 PM
4h 42m • 3 changes
2:02 PM → 6:45 PM
4h 43m • 3 changes
Show more

Departing Wednesday, October 14, 2026

5:27 AM → 10:19 AM
4h 52m • 3 changes
8:46 AM → 1:19 PM
4h 33m • 3 changes
1:37 PM → 6:19 PM
4h 42m • 3 changes
2:02 PM → 6:45 PM
4h 43m • 3 changes
Show more

Departing Thursday, October 15, 2026

5:27 AM → 10:19 AM
4h 52m • 3 changes
8:46 AM → 1:19 PM
4h 33m • 3 changes
1:37 PM → 6:19 PM
4h 42m • 3 changes
2:02 PM → 6:45 PM
4h 43m • 3 changes
Show more

Departing Friday, October 16, 2026

5:27 AM → 10:19 AM
4h 52m • 3 changes
8:46 AM → 1:19 PM
4h 33m • 3 changes
1:37 PM → 6:19 PM
4h 42m • 3 changes
2:02 PM → 6:45 PM
4h 43m • 3 changes
Show more

Frequently asked questions

Want to know about travelling from Irvine to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Irvine, CA, USA and Otay Mesa, CA, USA?

You can take a bus from University-Ent 3773 Mariposa Villa to Otay Mesa Rd & Cactus Rd via The Depot At Santa Ana Dock 3, Santa Ana, San Ysidro, San Ysidro Transit Center, and Iris Avenue Transit Center in around 4h 35m.

Operators

Find Transport to Otay Mesa

Trip Overview

Line 59 bus, bus

Irvine to Otay Mesa bus times

Departing Saturday, October 10, 2026

1:33 PM → 5:54 PM

4:15 PM → 8:54 PM

8:58 PM → 6:10 AMArrives next day

Departing Monday, October 12, 2026

5:27 AM → 10:19 AM

8:46 AM → 1:19 PM

1:37 PM → 6:19 PM

2:02 PM → 6:45 PM

Departing Tuesday, October 13, 2026

5:27 AM → 10:19 AM

8:46 AM → 1:19 PM

1:37 PM → 6:19 PM

2:02 PM → 6:45 PM

Departing Wednesday, October 14, 2026

5:27 AM → 10:19 AM

8:46 AM → 1:19 PM

1:37 PM → 6:19 PM

2:02 PM → 6:45 PM

Departing Thursday, October 15, 2026

5:27 AM → 10:19 AM

8:46 AM → 1:19 PM

1:37 PM → 6:19 PM

2:02 PM → 6:45 PM

Departing Friday, October 16, 2026

5:27 AM → 10:19 AM

8:46 AM → 1:19 PM

1:37 PM → 6:19 PM

2:02 PM → 6:45 PM

Frequently asked questions

What companies run services between Irvine, CA, USA and Otay Mesa, CA, USA?

Bus from University-Ent 3773 Mariposa Villa to The Depot At Santa Ana Dock 3

Bus trips from Irvine

Bus trips to Otay Mesa

Alternative transport options

8:58 PM → 6:10 AM
Arrives next day