Rome2Rio

Irvine to Palo Alto buses

Find Transport to Palo Alto

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Irvine and Palo Alto takes 12h 30m and the fastest bus takes 10h 50m. There is at least one bus per day from Irvine to Palo Alto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 30m
Duration
399 mi
Distance
$88
Average price
Once daily
Frequency

Irvine to Palo Alto bus times

Buses run once daily between Irvine and Palo Alto. The earliest departure is at 7:14 AM in the morning, and the last departure from Irvine is at 9:14 PM which arrives into Palo Alto at 6:02 PM. All services require a transfer at Artic - Dock 4 and take an average of 12h 30m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA11h 10m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA11h 10m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA11h 10m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA10h 50m • 3 changes
  •  → 

    Arrives next day

    OCTAOCTAHoang ExpressSanta Clara VTA20h 48m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA11h 10m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    OCTAOCTAHoang ExpressSanta Clara VTA11h 10m • 3 changes

Frequently asked questions

Want to know about travelling from Irvine to Palo Alto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Palo Alto.ExpandLaunch map view
  • Distance: 398.9 mi
  • Duration: 12h 30m

What companies run services between Irvine, CA, USA and Palo Alto, CA, USA?

Greyhound USA operates a bus from Anaheim Regional Transportation Intermodal Center to San Jose Diridon Station once daily. Tickets cost $65–100 and the journey takes 7h 50m.

Operators