Irvine to San Ysidro Buses

Irvine to San Ysidro buses

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Trip Overview

The average bus between Irvine and San Ysidro takes 4h 34m and the fastest bus takes 2h 52m. The bus service runs several times per day from Irvine to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 34m
Duration: 120 mi
Distance: $30
Average price: Every 4 hours
Frequency

Line 59 bus, bus via San Ysidro Transit Center

best

Take the bus from University-Ent 3773 Mariposa Villa to The Depot At Santa Ana Dock 3bus 59
Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...

3h 51m

$20–36

Irvine to San Ysidro bus times

Buses run every 4 hours between Irvine and San Ysidro. The earliest departure is at 5:27 AM in the morning, and the last departure from Irvine is at 10:26 PM which arrives into San Ysidro at 6:21 AM. All services require a transfer at The Depot At Santa Ana Dock 3 and take an average of 4h 34m. The schedules shown below are for the next available departures.

Departing Thursday, October 22, 2026

4:00 PM → 8:11 PM
4h 11m • 2 changes
7:19 PM → 10:11 PM
2h 52m • 2 changes
9:26 PM → 3:56 AM
Arrives next day
6h 30m • 2 changes
10:26 PM → 6:21 AM
Arrives next day
7h 55m • 2 changes

Departing Friday, October 23, 2026

5:27 AM → 9:26 AM
3h 59m • 2 changes
8:46 AM → 12:43 PM
3h 57m • 2 changes
1:37 PM → 5:30 PM
3h 53m • 2 changes
2:02 PM → 6:16 PM
4h 14m • 2 changes
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Departing Saturday, October 24, 2026

9:08 AM → 12:41 PM
3h 33m • 2 changes
1:33 PM → 5:26 PM
3h 53m • 2 changes
4:15 PM → 8:08 PM
3h 53m • 2 changes
7:06 PM → 10:37 PM
3h 31m • 2 changes
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Departing Monday, October 26, 2026

5:27 AM → 9:26 AM
3h 59m • 2 changes
8:46 AM → 12:43 PM
3h 57m • 2 changes
1:37 PM → 5:30 PM
3h 53m • 2 changes
2:02 PM → 6:16 PM
4h 14m • 2 changes
Show more

Departing Tuesday, October 27, 2026

5:27 AM → 9:26 AM
3h 59m • 2 changes
8:46 AM → 12:43 PM
3h 57m • 2 changes
1:37 PM → 5:30 PM
3h 53m • 2 changes
2:02 PM → 6:16 PM
4h 14m • 2 changes
Show more

Departing Wednesday, October 28, 2026

5:27 AM → 9:26 AM
3h 59m • 2 changes
8:46 AM → 12:43 PM
3h 57m • 2 changes
1:37 PM → 5:30 PM
3h 53m • 2 changes
2:02 PM → 6:16 PM
4h 14m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Irvine to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.