The average bus between Irvine and San Ysidro takes 3h 27m and the fastest bus takes 3h 14m. The bus service runs several times per day from Irvine to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Irvine and San Ysidro. The earliest departure is at 6:33 AM in the morning, and the last departure from Irvine is at 8:58 PM which arrives into San Ysidro at 12:25 AM. All services require a transfer at The Depot At Santa Ana Dock 3 and take an average of 3h 27m. The schedules shown below are for the next available departures.

3h 14m • 1 change

3h 34m • 1 change
Arrives next day

3h 33m • 1 change

3h 14m • 1 change

3h 34m • 1 change
Arrives next day

3h 33m • 1 change

3h 14m • 1 change

3h 34m • 1 change
Arrives next day

3h 33m • 1 change
Want to know about travelling from Irvine to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Irvine to San Ysidro. However, there are services departing from Irvine station and arriving at San Ysidro station via The Depot At Santa Ana Dock 3. The journey, including transfers, takes approximately 3h 27m.
Irvine to San Ysidro bus services, operated by OCTA, depart from University-Ent 3773 Mariposa Villa station.
Irvine to San Ysidro bus services, operated by OCTA, arrive at San Ysidro station.
The distance between Irvine and San Ysidro is 143.9 km. The road distance is 183 km.
You can take a bus from University-Ent 3773 Mariposa Villa to San Ysidro via The Depot At Santa Ana Dock 3 and Santa Ana in around 4h 4m.