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Irvine to Santa Fe Depot buses

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Trip Overview

The average bus between Irvine and Santa Fe Depot takes 6h 41m and the fastest bus takes 2h 56m. The bus runs, on average, 6 times per week from Irvine to Santa Fe Depot. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 41m
Duration
100 mi
Distance
$19
Average price
6 times a week
Frequency

Irvine to Santa Fe Depot bus times

Buses run 6 times a week between Irvine and Santa Fe Depot. The earliest departure is at 7:06 PM in the evening, and the last departure from Irvine is at 8:58 PM which arrives into Santa Fe Depot at 10:15 PM. All services require a transfer at Santa Ana Bus Stop and take an average of 6h 41m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    OCTAFlixbus USA2h 56m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    OCTAFlixbus USA2h 56m • 1 change

Departing Friday, November 13, 2026

  •  → 

    OCTAFlixbus USA2h 56m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    OCTAFlixbus USA3h 9m • 1 change
  •  → 

    Arrives next day

    OCTAFlixbus USA25h 17m • 1 change

Departing Monday, November 16, 2026

  •  → 

    OCTAFlixbus USA2h 56m • 1 change

Frequently asked questions

Want to know about travelling from Irvine to Santa Fe Depot? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Santa Fe Depot.ExpandLaunch map view
  • Distance: 100.3 mi
  • Duration: 6h 41m

What companies run services between Irvine, CA, USA and Santa Fe Depot, San Diego County, CA, USA?

You can take a bus from University-Ent 3773 Mariposa Villa to Santa Fe Depot via Santa Ana Bus Stop and San Diego in around 3h 38m.

Operators