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Isernia to Brindisi buses

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Trip Overview

The average bus between Isernia and Brindisi takes 16h 54m and the fastest bus takes 16h 49m. The bus runs, on average, 6 times per week from Isernia to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 54m
Duration
423 km
Distance
€40
Average price
6 times a week
Frequency

Isernia to Brindisi bus times

Buses run 6 times a week between Isernia and Brindisi. The service departs Isernia at 5:16 PM in the evening, which arrives into Brindisi at 10:05:00. All services require a transfer, and take on average 16h 54m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

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    Arrives next day

    FlixBusFlixBus16h 49m • 1 change

Departing Friday, November 6, 2026

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    Arrives next day

    FlixBusFlixBus16h 49m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    FlixBusFlixBus16h 49m • 1 change

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    FlixBusFlixBus16h 49m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    FlixBusFlixBus16h 49m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    FlixBusFlixBus17h 19m • 1 change

Frequently asked questions

Want to know about travelling from Isernia to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Isernia to Brindisi.ExpandLaunch map view
  • Distance: 422.7 km
  • Duration: 16h 54m

What companies run services between Isernia, Italy and Brindisi, Italy?

You can take a bus from Isernia to Brindisi via Foggia in around 7h 24m.

Operators