The average bus between Isernia and Florence takes 6h 12m and the fastest bus takes 5h 55m. The bus service runs several times per day from Isernia to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Isernia and Florence. The earliest departure is at 6:50 AM in the morning, and the last departure from Isernia is at 6:20 PM which arrives into Florence at 12:50 AM. All services require a transfer, and take on average 6h 12m. The schedules shown below are for the next available departures.

5h 55m • 1 change

6h 5m • 1 change

6h 25m • 1 change

6h 10m • 1 change

5h 55m • 1 change

6h 5m • 1 change

7h 30m • 1 change

6h 10m • 1 change

5h 55m • 1 change

6h 5m • 1 change

6h 25m • 1 change

6h 10m • 1 change

5h 55m • 1 change

6h 5m • 1 change

6h 25m • 1 change

6h 10m • 1 change
Want to know about travelling from Isernia to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isernia to Florence. However, there are services departing from Isernia station and arriving at Florence station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 12m.
Isernia to Florence bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
Isernia to Florence bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Florence Villa Constanza Bus Station.
Book your Isernia to Florence bus tickets online with ATM Azienda di Trasporti Molisana S.p.A., FlixBus and BlaBlaCar Bus.
The distance between Isernia and Florence is 344.3 km. The road distance is 449 km.
You can take a bus from Isernia to Florence Villa Constanza Bus Station via Roma, Autostazione Tiburtina in around 5h 51m.