The average bus between Isola Ortigia and Florence takes 17h 25m and the fastest bus takes 16h 10m. The bus service runs several times per day from Isola Ortigia to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Isola Ortigia and Florence. The earliest departure is at 7:05 AM in the morning, and the last departure from Isola Ortigia is at 4:35 PM which arrives into Florence at 8:45 AM. All services require a transfer, and take on average 17h 25m. The schedules shown below are for the next available departures.
Arrives next day

18h 40m • 1 change
Arrives next day

16h 10m • 1 change
Arrives next day

18h 40m • 1 change
Arrives next day

16h 10m • 1 change
Arrives next day

18h 40m • 1 change
Arrives next day

16h 10m • 1 change
Arrives next day

18h 40m • 1 change
Arrives next day

16h 10m • 1 change
Want to know about travelling from Isola Ortigia to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isola Ortigia to Florence. However, there are services departing from Isola Ortigia station and arriving at Florence station via Catania Airport. The journey, including transfers, takes approximately 17h 25m.
Isola Ortigia to Florence bus services, operated by Interbus, depart from Siracusa - Corso Gelone station.
Isola Ortigia to Florence bus services, operated by Interbus, arrive at Florence Villa Constanza Bus Station.
Book your Isola Ortigia to Florence bus tickets online with Interbus and FlixBus.
The distance between Isola Ortigia and Florence is 821.6 km. The road distance is 1,132 km.
You can take a bus from Siracusa - Corso Gelone to Florence Villa Constanza Bus Station via Catania Airport in around 16h 55m.