The average bus between Isola Ortigia and Sicily takes 3h 46m and the fastest bus takes 3h 44m. The bus service runs several times per day from Isola Ortigia to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Isola Ortigia and Sicily. The earliest departure is at 8:00 AM in the morning, and the last departure from Isola Ortigia is at 5:00 PM which arrives into Sicily at 8:45 PM. All services require a transfer at Palermo station and take an average of 3h 46m. The schedules shown below are for the next available departures.

3h 45m • 1 change

3h 50m • 1 change

3h 45m • 1 change

3h 45m • 1 change

3h 45m • 1 change

3h 50m • 1 change

3h 45m • 1 change

3h 45m • 1 change

3h 45m • 1 change

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3h 45m • 1 change

3h 45m • 1 change

3h 45m • 1 change

3h 50m • 1 change

3h 45m • 1 change

3h 45m • 1 change
Want to know about travelling from Isola Ortigia to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isola Ortigia to Sicily. However, there are services departing from Isola Ortigia station and arriving at Sicily station via Palermo station station. The journey, including transfers, takes approximately 3h 46m.
Isola Ortigia to Sicily bus services, operated by Interbus, depart from Siracusa Bus Terminal station.
Isola Ortigia to Sicily bus services, operated by Interbus, arrive at Palermo station.
The distance between Isola Ortigia and Sicily is 116.5 km. The road distance is 261 km.
Interbus operates a bus from Siracusa Bus Terminal to Palermo station 4 times a day. Tickets cost €13–35 and the journey takes 3h 15m.