The average bus between Issy-les-Moulineaux and Brussels takes 4h 52m and the fastest bus takes 4h 24m. There is a bus service every few hours from Issy-les-Moulineaux to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Issy-les-Moulineaux and Brussels. The earliest departure is at 6:41 AM in the morning, and the last departure from Issy-les-Moulineaux is at 9:51 PM which arrives into Brussels at 3:05 AM. All services require a transfer at Quai de la Gare and take an average of 4h 52m. The schedules shown below are for the next available departures.

4h 31m • 1 change

4h 43m • 1 change

4h 41m • 1 change

5h 16m • 1 change

4h 49m • 1 change

4h 36m • 1 change

5h • 1 change

5h 12m • 1 change

4h 41m • 1 change

4h 48m • 1 change

4h 56m • 1 change

5h 21m • 1 change
Want to know about travelling from Issy-les-Moulineaux to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Issy-les-Moulineaux to Brussels. However, there are services departing from Issy-les-Moulineaux station and arriving at Brussels station via Brussels - Midi Train Station station. The journey, including transfers, takes approximately 4h 52m.
Issy-les-Moulineaux to Brussels bus services, operated by Seine Orly, depart from Paris - Bercy-Seine Bus Station.
Issy-les-Moulineaux to Brussels bus services, operated by Seine Orly, arrive at Brussels - Midi Train Station.
The distance between Issy-les-Moulineaux and Brussels is 270.2 km. The road distance is 305 km.
BlaBlaCar Bus operates a bus from Paris - Bercy-Seine Bus Station to Brussels - Midi Train Station every 30 minutes. Tickets cost €26–50 and the journey takes 3h 50m.