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Jacksonville to Big Pine Key buses

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Trip Overview

The average bus between Jacksonville and Big Pine Key takes 19h 22m and the fastest bus takes 16h 50m. There is at least one bus per day from Jacksonville to Big Pine Key. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

19h 22m
Duration
542 mi
Distance
$116
Average price
Once daily
Frequency

Jacksonville to Big Pine Key bus times

Buses run once daily between Jacksonville and Big Pine Key. The earliest departure is at 10:30 AM in the morning, and the last departure from Jacksonville is at 3:50 PM which arrives into Big Pine Key at 8:40 AM. All services require a transfer, and take on average 19h 22m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USAGreyhound USA16h 50m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    Flixbus USAGreyhound USA16h 50m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAGreyhound USA22h 10m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAGreyhound USA22h 10m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USAGreyhound USA16h 50m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Flixbus USAGreyhound USA16h 50m • 1 change

Frequently asked questions

Want to know about travelling from Jacksonville to Big Pine Key? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Jacksonville to Big Pine Key.ExpandLaunch map view
  • Distance: 541.8 mi
  • Duration: 19h 22m

What companies run services between Jacksonville, FL, USA and Big Pine Key, FL, USA?

You can take a bus from Jacksonville to Big Pine Key via Miami Airport Station in around 13h 55m.

Operators