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Jeffersonville to Chicago buses

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Trip Overview

The average bus between Jeffersonville and Chicago takes 8h 17m and the fastest bus takes 5h 50m. There is at least one bus per day from Jeffersonville to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 17m
Duration
302 mi
Distance
$58
Average price
Once daily
Frequency

Bus

best
  1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
7h 39m
$42–78

Jeffersonville to Chicago bus times

Buses run once daily between Jeffersonville and Chicago. The earliest departure is at 5:55 AM in the morning, and the last departure from Jeffersonville is at 9:49 PM which arrives into Chicago at 8:25 AM. All services require a transfer at W Jefferson @ S 6th and take an average of 8h 17m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

  •  → 

    Transit Authority of River CityTransit Authority of River CityGreyhound USA7h 11m • 2 changes

  •  → 

    Arrives next day

    Transit Authority of River CityTransit Authority of River CityFlixbus USA5h 50m • 2 changes

  •  → 

    Arrives next day

    Transit Authority of River CityTransit Authority of River CityGreyhound USA11h 35m • 2 changes

Departing Sunday, October 11, 2026

  •  → 

    Transit Authority of River CityTransit Authority of River CityGreyhound USA9h 14m • 2 changes

  •  → 

    Transit Authority of River CityTransit Authority of River CityGreyhound USA7h 35m • 2 changes

  •  → 

    Transit Authority of River CityTransit Authority of River CityGreyhound USA7h 11m • 2 changes

  •  → 

    Arrives next day

    Transit Authority of River CityTransit Authority of River CityFlixbus USA5h 50m • 2 changes
  • Show more

Frequently asked questions

Want to know about travelling from Jeffersonville to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Jeffersonville to Chicago.ExpandLaunch map view
  • Distance: 302.4 mi
  • Duration: 8h 17m

What companies run services between Jeffersonville, IN, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–75 and the journey takes 6h. Flixbus USA also services this route twice daily.

Operators