The average bus between Karlsruhe and Duisburg takes 7h 55m and the fastest bus takes 6h 25m. The bus service runs several times per day from Karlsruhe to Duisburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Karlsruhe and Duisburg. The earliest departure is at 1:50 AM at night, and the last departure from Karlsruhe is at 11:55 PM which arrives into Duisburg at 7:25 AM. All services require a transfer, and take on average 7h 55m. The schedules shown below are for the next available departures.

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Want to know about travelling from Karlsruhe to Duisburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Karlsruhe to Duisburg. However, there are services departing from Karlsruhe station and arriving at Duisburg station via Düsseldorf central bus station station. The journey, including transfers, takes approximately 7h 55m.
Karlsruhe to Duisburg bus services, operated by FlixBus, depart from Karlsruhe central train station.
Karlsruhe to Duisburg bus services, operated by FlixBus, arrive at Düsseldorf central bus station.
Book your Karlsruhe to Duisburg bus tickets online with FlixBus.
The distance between Karlsruhe and Duisburg is 293.6 km. The road distance is 388 km.
FlixBus operates a bus from Karlsruhe central train station to Düsseldorf central bus station every 3 hours. Tickets cost €30–55 and the journey takes 5h 35m.