The average bus between Karlsruhe and Mainz takes 3h 11m and the fastest bus takes 2h 44m. The bus service runs several times per day from Karlsruhe to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Karlsruhe and Mainz. The earliest departure is at 1:15 AM at night, and the last departure from Karlsruhe is at 9:50 PM which arrives into Mainz at 1:49 AM. All services require a transfer at Frankfurt Airport and take an average of 3h 11m. The schedules shown below are for the next available departures.

5h 59m • 1 change

3h 14m • 1 change
Arrives next day

3h 59m • 1 change

5h 24m • 1 change

3h 9m • 1 change

5h 9m • 1 change

2h 44m • 1 change

5h 24m • 1 change

3h 9m • 1 change

5h 9m • 1 change

2h 44m • 1 change

5h 24m • 1 change

3h 9m • 1 change

5h 9m • 1 change

2h 44m • 1 change

5h 24m • 1 change

5h 9m • 1 change

2h 44m • 1 change

4h 54m • 1 change
Want to know about travelling from Karlsruhe to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Karlsruhe to Mainz. However, there are services departing from Karlsruhe station and arriving at Mainz station via Frankfurt Airport. The journey, including transfers, takes approximately 3h 11m.
Karlsruhe to Mainz bus services, operated by FlixBus, depart from Karlsruhe central train station.
Karlsruhe to Mainz bus services, operated by FlixBus, arrive at Ginsheim-Gustavsburg-Gustavsburg Am Alten Fährhaus station.
Book your Karlsruhe to Mainz bus tickets online with FlixBus, DB Bus and BlaBlaCar Bus.
The distance between Karlsruhe and Mainz is 108.8 km. The road distance is 177 km.
You can take a bus from Karlsruhe central train station to Ginsheim-Gustavsburg-Gustavsburg Am Alten Fährhaus via Frankfurt Airport and Frankfurt in around 3h 11m.