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Key Largo to Fort Myers Beach buses

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Trip Overview

The average bus between Key Largo and Fort Myers Beach takes 14h 44m and the fastest bus takes 7h 53m. The bus service runs several times per day from Key Largo to Fort Myers Beach. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

14h 44m
Duration
248 mi
Distance
$52
Average price
Twice daily
Frequency

Key Largo to Fort Myers Beach bus times

Buses run twice daily between Key Largo and Fort Myers Beach. The earliest departure is at 12:55 PM in the afternoon, and the last departure from Key Largo is at 8:00 PM which arrives into Fort Myers Beach at 12:58 PM. All services require a transfer at Miami Airport Station and take an average of 14h 44m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit16h 58m • 4 changes

Departing Wednesday, November 11, 2026

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    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit7h 53m • 4 changes
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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit16h 58m • 4 changes

Departing Thursday, November 12, 2026

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    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit7h 53m • 4 changes
  •  → 

    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit16h 58m • 4 changes

Departing Friday, November 13, 2026

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    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit7h 53m • 4 changes
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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit17h 56m • 4 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit21h 9m • 4 changes
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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit17h 56m • 4 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit18h 15m • 4 changes
  •  → 

    Arrives next day

    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit16h 58m • 4 changes

Departing Monday, November 16, 2026

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    Greyhound USAFlixbus USALee County TransitLee County TransitLee County Transit7h 53m • 4 changes

Frequently asked questions

Want to know about travelling from Key Largo to Fort Myers Beach? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key Largo to Fort Myers Beach.ExpandLaunch map view
  • Distance: 247.9 mi
  • Duration: 14h 44m

What companies run services between Key Largo, FL, USA and Fort Myers Beach, FL, USA?

You can take a bus from Key Largo Bus Stop to Estero Blvd @ Crescent Beach Park via Miami Airport Station, Rosa Parks Transportation Ctr, Edison Mall Transfer Ctr, and Beach Park & Ride in around 8h 31m.

Operators