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Key West (Island) to Jacksonville buses

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Trip Overview

The average bus between Key West (Island) and Jacksonville takes 22h and the fastest bus takes 21h 20m. There is at least one bus per day from Key West (Island) to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h
Duration
572 mi
Distance
$124
Average price
Once daily
Frequency

Key West (Island) to Jacksonville bus times

Buses run once daily between Key West (Island) and Jacksonville. The service departs Key West (Island) at 5:00 PM in the evening, which arrives into Jacksonville at 14:20:00. All services require a transfer, and take on average 22h. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives next day

    Greyhound USAFlixbus USA21h 20m • 1 change

Departing Thursday, November 5, 2026

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    Arrives next day

    Greyhound USAFlixbus USA21h 20m • 1 change

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USA21h 45m • 1 change

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA21h 20m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAFlixbus USA21h 20m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA21h 45m • 1 change

Frequently asked questions

Want to know about travelling from Key West (Island) to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West (Island) to Jacksonville.ExpandLaunch map view
  • Distance: 571.6 mi
  • Duration: 22h

What companies run services between Key West (Island), FL, USA and Jacksonville, FL, USA?

You can take a bus from Key West Airport to Jacksonville via Miami Airport Station in around 14h 25m.

Operators