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Key West to Biloxi buses

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Trip Overview

The average bus between Key West and Biloxi takes 31h 24m and the fastest bus takes 29h 55m. The bus runs, on average, 5 times per week from Key West to Biloxi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 24m
Duration
1,296 mi
Distance
$269
Average price
5 times a week
Frequency

Key West to Biloxi bus times

Buses run 5 times a week between Key West and Biloxi. The service departs Key West at 4:15 PM in the afternoon, which arrives into Biloxi at 21:10:00. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 31h 24m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAGreyhound USAGreyhound USAFlixbus USA29h 55m • 4 changes

Departing Saturday, October 31, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAGreyhound USAGreyhound USAFlixbus USA30h 55m • 4 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAGreyhound USAGreyhound USAFlixbus USA29h 55m • 4 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAGreyhound USAGreyhound USAFlixbus USA29h 55m • 4 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USAGreyhound USA36h 20m • 4 changes

Frequently asked questions

Want to know about travelling from Key West to Biloxi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Biloxi.ExpandLaunch map view
  • Distance: 1,295.6 mi
  • Duration: 31h 24m

What companies run services between Key West, FL, USA and Biloxi, MS, USA?

You can take a bus from N Roosevelt & 3rd Street to Biloxi via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, Garnett Station, Doraville Station, and Atlanta in around 27h 30m.

Operators