Rome2Rio

Key West to Birmingham buses

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Trip Overview

The average bus between Key West and Birmingham takes 24h 50m and the fastest bus takes 24h 26m. There is at least one bus per day from Key West to Birmingham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

24h 50m
Duration
981 mi
Distance
$212
Average price
Once daily
Frequency

Key West to Birmingham bus times

Buses run once daily between Key West and Birmingham. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Birmingham at 6:30 PM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 24h 50m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAGreyhound USAGreyhound USA27h 15m • 3 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA24h 26m • 3 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA24h 26m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA24h 26m • 3 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA24h 26m • 3 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA24h 26m • 3 changes

Frequently asked questions

Want to know about travelling from Key West to Birmingham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Birmingham.ExpandLaunch map view
  • Distance: 980.8 mi
  • Duration: 24h 50m

What companies run services between Key West, FL, USA and Birmingham, AL, USA?

You can take a bus from N Roosevelt & 3rd Street to Birmingham Intermodal Facility via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 23h 27m.

Operators