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Key West to Winston-Salem buses

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Trip Overview

The average bus between Key West and Winston-Salem takes 2d 6h and the fastest bus takes 2d 5h. The bus runs, on average, 2 times per week from Key West to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 6h
Duration
1,082 mi
Distance
$211
Average price
Twice a week
Frequency

Key West to Winston-Salem bus times

Buses run twice a week between Key West and Winston-Salem. The service departs Key West at 4:15 PM in the afternoon, which arrives into Winston-Salem at 21:45:00. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 2d 6h. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAFlixbus USAGreyhound USA2d 6h • 3 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAFlixbus USAGreyhound USA2d 5h • 3 changes

Frequently asked questions

Want to know about travelling from Key West to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Winston-Salem.ExpandLaunch map view
  • Distance: 1,082.1 mi
  • Duration: 2d 6h

What companies run services between Key West, FL, USA and Winston-Salem, NC, USA?

You can take a bus from N Roosevelt & 3rd Street to Winston Salem(Trans Center) via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Fayetteville Bus Station in around 27h 17m.

Operators