The average bus between L'Isle-sur-la-Sorgue and Lyon takes 4h 56m and the fastest bus takes 4h 15m. The bus service runs several times per day from L'Isle-sur-la-Sorgue to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between L'Isle-sur-la-Sorgue and Lyon. The earliest departure is at 6:45 AM in the morning, and the last departure from L'Isle-sur-la-Sorgue is at 6:50 PM which arrives into Lyon at 11:05 PM. All services require a transfer at Limbert/Remparts and take an average of 4h 56m. The schedules shown below are for the next available departures.


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Want to know about travelling from L'Isle-sur-la-Sorgue to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from L'Isle-sur-la-Sorgue to Lyon. However, there are services departing from L'Isle-sur-la-Sorgue station and arriving at Lyon station via Lyon. The journey, including transfers, takes approximately 4h 56m.
L'Isle-sur-la-Sorgue to Lyon bus services, operated by ZOU! Proximité, depart from Avignon station.
L'Isle-sur-la-Sorgue to Lyon bus services, operated by ZOU! Proximité, arrive at Lyon station.
Book your L'Isle-sur-la-Sorgue to Lyon bus tickets online with ZOU! Proximité, Tecelys and 2 other operators.
The distance between L'Isle-sur-la-Sorgue and Lyon is 204 km. The road distance is 268 km.
FlixBus operates a bus from Avignon to Lyon every 4 hours. Tickets cost €19–35 and the journey takes 2h 40m. BlaBlaCar Bus also services this route every 4 hours.