Rome2Rio

La Crosse to Indianapolis buses

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Trip Overview

The average bus between La Crosse and Indianapolis takes 21h 38m and the fastest bus takes 21h 20m. The bus runs, on average, 6 times per week from La Crosse to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 38m
Duration
474 mi
Distance
$119
Average price
6 times a week
Frequency

La Crosse to Indianapolis bus times

Buses run 6 times a week between La Crosse and Indianapolis. The service departs La Crosse at 2:30 PM in the afternoon, which arrives into Indianapolis at 12:45:00. All services require a transfer at Milwaukee and take an average of 21h 38m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA22h 15m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA22h 15m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA21h 20m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA21h 20m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA21h 20m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA21h 20m • 2 changes

Frequently asked questions

Want to know about travelling from La Crosse to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Crosse to Indianapolis.ExpandLaunch map view
  • Distance: 473.9 mi
  • Duration: 21h 38m

What companies run services between La Crosse, WI, USA and Indianapolis, IN, USA?

You can take a bus from La Crosse to Indianapolis via Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 11h 10m.

Operators